Causes

06/01/2018

Genes: Over 50 genes have been found more often in Lupus patients than those without Lupus, leading researchers to believe that they contribute to cause of Lupus. A specific group genes known as Major Histocompatibility Complex (MHC) genes. These genes contribute to the function of the immune system. This is why many believe it may be linked to the autoimmunity of Lupus. It has also been founds that in twin siblings, if one has Lupus, there is an increased chance that the other will also develop Lupus. Although Lupus can develop in an individual even if there is no trace of it in their family history, it is likely that other types of autoimmune diseases were present. It has also been found that members of certain ethnic groups are more likely to develop Lupus. (More information on the Genetics and Treatments section of the website)
Hormones: According to the Lupus Foundation of America, 9 out of 10 Lupus patients are female. This has led researchers to hypothesize that there is a connection between estrogen, a hormone that is more prevalent in females in males, and Lupus. It was also found that women are more likely to experience symptoms of Lupus when their estrogen levels are high, such as during menstrual periods and pregnancy.
Environment: Many researchers believe that a virus, chemical or other environmental factor. While no specific environmental factor has been proven to independently cause Lupus, the following have been suggested as possibilities:

UV rays from the sun
Drugs/medicine that make the individual more sensitive to the sun
Certain antibiotics
Exhaustion
Infections, cold/flu, viral illnesses
Emotional stress
Physical stresses to the body including an injury, pregnancy, giving birth, etc.

It is important to note that while these factors may cause Lupus in one individual, it may not cause Lupus in another.